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PBL/人干扰素αA（α2a）/5 x 10⁶units/11100-1

商品编号： 11100-1

品牌： PBL

市场价： ¥5000.00

美元价： 2500.00

产地：美国(厂家直采)

公司：

产品分类：引物

公司分类： primer

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Human IFN Alpha A (Alpha 2a)

Product Features:

Human IFN Alpha 2a recombinant protein with high activity
95% or greater purity

Catalog No.	Pack Size	Price	Quantity
11100-1	5 x 10⁶ units	$250.00

Specifications
Tech Info / Data
Citations
Documentation

Specifications

Formulation	Supplied frozen in phosphate-buffered saline (PBS) containing 0.1% Bovine Serum Albumin (BSA)
Molecular Weight	19.2 kDa
Source	cDNA obtained from human leukocyte mRNA expressed in E.coli
Purity	> 95% by SDS-PAGE stained by Coomassie Blue
Bioactivity	Measured using a cytopathic inhibition assay on Bovine Kidney Cells (MDBK) with Vesicular Stomatis Virus (VSV); human lung carcinoma cell line A549 with encephalomyocarditis virus (EMCV)
Storage	For retention of full activity store at -70 ºC or below and avoid repeated freeze-thaw cycles
Synonyms	Interferon alpha A, IFN alpha A, IFNaA, IFN alpha 2a, IFN alpha A, IFN-a, interferon alpha, IFN-a2a, interferon alpha 2a, Leukocyte interferon, Leukocyte IFN, alpha interferon, interferon alfa, IFN alfa, interferon alpha 2a, IFN alpha 2a, interferon a, Type I interferon alpha, Type I IFN alpha
Accession Number	V00549

Tech Info / Data

Application Notes:

A Comparison of the Binding of Interferon Alpha Subtypes to Isolated IFNAR1 and IFNAR2 with Activity in Antiviral and Antiproliferative Assays (link)

Background:

Recombinant Human Interferon Alpha A (alpha 2a) obtained from human leukocyte mRNA expressed in E.coli.

IFN alpha 2a is one of the many interferon alpha subtypes belonging to the Type I leukocyte IFN family. The Type I IFN family has antiviral, anti-proliferative and natural killer cell activities. IFN alpha 2a and b are the most widely used therapeutic IFN alphas.

Citations

40 Citations:

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Sharma, Amit, et al. (2019). Macaque interferon-induced transmembrane proteins limit replication of SHIV strains in an Envelope-dependent manner. PLOS Pathogens, 23 pgs. PMID: 31260493. (link)

Williams, Katherine, et al. (2019). Identification of HIV gp41-specific antibodies that mediate killing of infected cells. PLOS Pathogens, 27 pgs. PMID: 30779811. (link)

Perucha, Esperanza, et al. (2019). The cholesterol biosynthesis pathway regulates IL-10 expression in human Th1 cells. Nature Communications, 13 pgs. PMID: 30700717. (link)

DeMarino, Catherine, et al. (2018). Antiretroviral Drugs Alter the Content of Extracellular Vesicles from HIV-1 Infected Cells. Scientific Reports, 20 pgs. PMID: 29769566. (link)

Couret, Jennifer, et al. (2017). Differential Regulation of IFN-alpha, IFN-beta, and IFN-epsilon Gene Expression in Human Cervical Epithelial Cells. Cell & Bioscience, 6 pgs. PMID: 29118969. (link)

Lin, Gloria, et al. (2017). TTI-621 (SIRP-alpha-Fc), a CD47-Blocking Cancer Immunotherapeutic, Triggers Phagocytosis of Lymphoma Cells by Multiple Polarized Macrophage Subsets . PLOS One, 16 pgs. PMID: 29084248. (link)

von Stemann, Jakob H, et al. (2017). Prevalence and correlation of cytokine-specific autoantibodies with epidemiological factors and C-reactive protein in 8,972 healthy individuals: Results from the Danish Blood Donor Study. PLOS One, 17 pgs. PMID: 28665954. (link)

Wang, Qiang, et al. (2017). The E3 Ubiquitin Ligase RNF185 Facilitates the cGAS-Mediated Innate Immune Response. PLOS Pathogens, 25 pgs. PMID: 28273161. (link)

Kalkavan, Halime, et al. (2017). Spatiotemporally Restricted Arenavirus Replication Induces Immune Surveillance and Type I Interferon-Dependent Tumour Regression. Nature Communications, 14 pgs. PMID: 28248314. (link)

Jonsson, K, et al. (2017). IFI16 is Required for DNA Sensing in Human Macrophages by Promoting Production and Function of cGAMP. Nature Communications, 17 pgs. PMID: 28186168. (link)

Rahman, Masmudur, et al. (2017). Myxoma Virus dsRNA Binding Protein M029 Inhibits the Type I IFN-Induced Antiviral State in a Highly Species-Specific Fashion. Viruses, 22 pgs. PMID: 28157174. (link)

Niu, Congrong, et al. (2017). The Smc5/6 Complex Restricts HBV When Localized to ND10 Without Inducing an Innate Immune Response and is Counteracted by the HBV X Protein Shortly After Infection. PLOS One, 32 pgs. PMID: 28095508. (link)

Iyer, Shilpa, et al. (2017). Resistance to Type I Interferons is a Major Determinant of HIV-1 Transmission Fitness. PNAS, 10 pgs. PMID: 28069935. (link)

Schwartz, Jordan (2017). Elucidation of the Plasmacytoid Dendritic Cell Response to HIV-1. University of Toronto, 190 pgs. PMID: no PMID. (no link)

Tasker, Carley, et al. (2016). IFN-epsilon Protects Primary Macrophages Against HIV Infection. JCI Insight, 17 pgs. PMID: 27942584. (link)

Yamauchi, Shota, et al. (2016). STAT1 is Essential For the Inhibition of Hepatitis C Virus Replication by Interferon-lambda but Not by Interferon-alpha. Scientific Reports, 11 pgs. PMID: 27929099. (link)

Pham, Tram, et al. (2016). Enhancing Virion Tethering by BST2 Sensitizes Productively and Latently HIV-Infected T Cells to ADCC Mediated by Broadly Neutralizing Antibodies. Scientific Reports, 15 pgs. PMID: 27853288. (link)

Eschbaumer, Michael, et al. (2016). Systemic Immune Response and Virus Persistence After Foot-and-Mouth Disease Virus Infection of Naive Cattle and Cattle Vaccinated With a Homologous Adenovirus-Vectored Vaccine. BMC Veterinary Research, 18 pgs. PMID: 27634113. (link)

Millrine, David, et al. (2016). Rabex-5 is a lenalidomide target molecule that negatively regulates TLR-induced type 1 IFN production. PNAS, 6 pgs. PMID: 27601648. (link)

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