Mouse IFN Beta, mammalian
- Specifications
- Tech Info / Data
- Citations
- Documentation
Specifications
| Formulation | Supplied frozen in 20mM Sodium Phosphate pH 6.4; 300mM NaCl; 5% Glycerol; 0.1% Bovine Serum Albumin (BSA) |
| Molecular Weight | 19.6 kDa |
| Source | Gene obtained from mouse DNA expressed in mammalian cells |
| Purity | > 95% by SDS-PAGE stained by Coomassie BlueEndotoxin level < 1 EU/μg |
| Bioactivity | Measured using a cytopathic effect inhibition assay on Mouse (L929) cells with EMCVEC50 for IFN Beta is ~ 2.5 U/ml |
| Storage | For retention of full activity store at -70°C or below and avoid repeated freeze/thaw cycles |
| Synonyms | Mouse Beta Interferon, Mouse IFN Beta, Mouse IFNB, Mouse Type I IFN beta, Mouse Fibroblast IFN, Mouse Fibroblast Interferon, Mouse Beta IFN, Mouse Type I Interferon Beta |
| Accession Number | K00020 |
Tech Info / Data
Interferons (IFNs) are a family of mammalian cytokines produced by macrophages, neutrophils, dendritic cells and other somatic cells in response to viruses and pathogens. IFN Beta is classified as a type I IFN and is produced by fibroblast and a variety of cell types in response to viral challenge. Although all type I IFNs bind to the same type I IFN receptor complex, studies have shown that IFN Beta signals differently than IFN Alpha. Furthermore, it has been shown that IFN Beta exerts preferential induction of apoptotic effect on melanoma cells. These findings, along with the therapeutic use of IFN Beta in Multiple Sclerosis and hepatitis C, make further understanding of IFN Beta biological activities an important area of research.
The mammalian expressed mouse IFN Beta protein is designed to provide scientists with a highly active recombinant protein that closely resembles native mouse IFN Beta.
Citations
Documentation
12405-1 Certificate of Analysis (CoA) Product Flyer SDSMammalian expressed (12405) vs. E.coli expressed (12400) mouse IFN-Beta as measured in L929/EMCV CPE activity assay
Results are representative and may vary depending upon experimental conditions
