Human IL-22 ELISA (High Sensitivity)
- Specifications
- Tech Info / Data
- Citations
- Documentation
Specifications
Compatibility: Serum, Plasma, Tissue Culture MediaELISA Assay Range: 0.78 - 50 pg/mlAssay Length: 4 hoursSpecificity: Human Interleukin 22Cross-reacts with Monkey IL-22 (< 0.03%).No cross-reactivity detected with human IL-10, IL-17, IL-19, IL-20, IL-24, IL-26/AK155, IFN-β1a, IFN-γ, IFN-ω; cynomolgus IFN-α2; cynomolgus/rhesus IFN-α; mouse IL-22, IFN-αA, IFN-β, IFN-γ; rat IL-22, IFN-α1, IFN-α14, IFN-β, IFN-γ; bovine IFN-Tau2 or pig IFN-α.
Inter-Assay CV: < 10%Intra-Assay CV: < 10%Spike recovery: > 96%
Storage: 2-8 °CExpiration Date: one year from date of manufactureShipping Condition: Wet Ice
Materials Provided:
- Pre-Coated Micro-Titer Stripwell Plate/Sealers
- Wash Solution Concentrate
- Human Interleukin-22 Standard (10,000 pg/ml)
- Standard Diluent
- Assay Buffer
- Antibody Concentrate
- HRP Conjugate Concentrate
- Concentrate Diluent
- HRP Diluent
- TMB Substrate Solution
- Stop Solution
Tech Info / Data
Detailed Related Product Information:
- Quantitative Immunoassays: Single Analyte Screening Services
Interleukin 22 (IL-22) is a member of the IL-10 family of cytokines1. Other names include IL-TIF and Zcyto18. IL-22 is produced by a variety of cells including Th1, Th17, Th22 T-cells, NKT cells, ILC3, neutrophils and macrophages2. Targeting primarily non-hemopoietic cells such as stromal and epithelial cells, IL-22 exerts both protective effects, such as hepatocyte and epithelial cell survival, and pro-inflammatory effects. It is also implicated in autoimmune diseases such as Systemic Lupus Erythematosus, Rheumatoid Arthritis and Psoriasis3. IL-22 is often considered a hallmark of IL-17 driven immune responses4.
References:
- Dumoutier, L., et al. 2000. Genes & Immunity. 1(8): 488-94.
- Dudakov J., Hanash A., van den Brink, M. 2015. Annual Review of Immunology. 33: 747-785.
- Eyerich, K., Dimartino, V., Cavani, A. 2017. European Journal of Immunology. 47(4): 607-614.
- Eyerich, S., et al. 2017. Allergologie Select. 1(1): 71-76.
Citations
Documentation
41701 Certificate of Analysis & Protocol (One-Page) 41701 Technical Data Sheet Safety Data Sheet (SDS) 41701 FlyerHigh Sensitivity Human IL-22 ELISA exhibits high detectability of endogenous IL-22 in autoimmune/IL-22 related disease sera
